search("condroprotectores perros 2023 site:pubmed.ncbi.nlm.nih.gov")

search("chondroprotectors dogs 2023 site:pubmed.ncbi.nlm.nih.gov")

  * DOI:  【33† 10.5455/OVJ.2023.v13.i3.6 †doi.org】 

Free PMC article

Item in Clipboard 

#  Postoperative efficacy of chondroprotectors and diacerein in dogs with osteoarthritis secondary to cranial cruciate ligament disease 

Florencia Sollier Podestá et al. Open Vet J. 2023 Mar.

Free PMC article

 Show details

Display options

Display options 

Format   Abstract PubMed PMID

 Open Vet J 

Actions

  * 【27† Search in PubMed 】
  * 【28† Search in NLM Catalog †www.ncbi.nlm.nih.gov】
  * Add to Search 

. 2023 Mar;13(3):297-306.

doi: 10.5455/OVJ.2023.v13.i3.6.  Epub 2023 Mar 9. 

###  Authors 

【29†Florencia Sollier Podestá】 【34† 1 】, 【31†Daniela Fabiana Izquierdo Caquías】 【34† 1 】

###  Affiliation 

  * ^{1} Small Animal Surgery and Anesthesia Unit, Department of Clinics and Veterinary Hospital, Faculty of Veterinary Medicine, Universidad de la República, Montevideo, Uruguay.

  * PMID:  37026069
  * PMCID:  【32† PMC10072838 †www.ncbi.nlm.nih.gov】 
  * DOI:  【33† 10.5455/OVJ.2023.v13.i3.6 †doi.org】 

Item in Clipboard 

Full text links Cite 

Display options

Display options 

Format Abstract PubMed PMID

##  Abstract 

Background:  Cranial cruciate ligament disease is one of the leading causes of pelvic limb claudication in canines and osteoarthritis in the stifle joint. Historically, studies have focused on surgical options to improve the stability of the stifle joint, although none of the techniques described in the literature prevents the development of osteoarthritis. 

Aim:  This study aimed at proving the presence of osteoarthritis at the time of diagnosis of cranial cruciate ligament rupture, as well as evaluating the benefits of administering diacerein (DAR) or chondroprotective coadjuvants to the extracapsular fabelo-tibial technique. 

Methods:  Seventeen dogs aged between 2 and 8, weighing more than 25 kg, with no predilection for breed or sex, were operated on using this technique. These were divided into three groups: DAR, Chondroprotector (CP), and Control. The animals were treated for 90 days and controlled clinically, radiologically, and using multidimensional scales for pain and quality of life. The statistical analysis used was descriptive and through non-parametric tests. 

Results:  All patients had some degree of osteoarthritis at the beginning of the study associated with the presence of pain. The treated groups improved the claudication scores; however, the changes were significant for the DAR group. The pain score improved in all animals, including those in the Control group; however, the differences were significant only in the treated groups. On the other hand, no significant differences were detected in the radiological studies, so it would be convenient to perform this study over more than 90 days. 

Conclusion:  The surgical treatment accompanied by drugs that act on the degradation of articular cartilage has better clinical results. 

Keywords:  Cruciate ligament; Degenerative disease; Dogs; Joint regeneration; Stifle joint. 

 【35†PubMed Disclaimer】 

##  Conflict of interest statement 

The Authors declare that there is no conflict of interest.

##  Figures 

  【36†  †www.ncbi.nlm.nih.gov】 

Fig. 1.. Mean claudication score of the… 

Fig. 1.. Mean claudication score of the study groups. The behavior of the control group,… 

  Fig. 1.. Mean claudication score of the study groups. The behavior of the control group, CP, and diacerein is shown.  【37†  †www.ncbi.nlm.nih.gov】 

Fig. 2.. Scoring for the degree and… 

Fig. 2.. Scoring for the degree and progression of osteoarthritis according to the Bioarth scale.… 

  Fig. 2.. Scoring for the degree and progression of osteoarthritis according to the Bioarth scale. The curves represent the average median values of the observers for the control group, CP, and diacerein.  【38†  †www.ncbi.nlm.nih.gov】 

Fig. 3.. Evaluation of quality of life… 

Fig. 3.. Evaluation of quality of life according to the HCPI. The curves represent the… 

  Fig. 3.. Evaluation of quality of life according to the HCPI. The curves represent the means of the values for the control group, CP, and diacerein.  【39†  †www.ncbi.nlm.nih.gov】 

Fig. 4.. Evaluation of quality of life… 

Fig. 4.. Evaluation of quality of life according to the CBPI. The curves represent the… 

  Fig. 4.. Evaluation of quality of life according to the CBPI. The curves represent the means of the values for the control group, CP, and diacerein. 

See this image and copyright information in PMC 

##  Similar articles 

  * 【40† Long-term radiographic comparison of tibial plateau leveling osteotomy versus extracapsular stabilization for cranial cruciate ligament rupture in the dog. 】 

Lazar TP, Berry CR, deHaan JJ, Peck JN, Correa M. Lazar TP, et al. Vet Surg. 2005 Mar-Apr;34(2):133-41. doi: 10.1111/j.1532-950X.2005.00021.x. Vet Surg. 2005. PMID: 15860104

  * 【41† Diagnostic accuracy of a short-duration 3 Tesla magnetic resonance protocol for diagnosing stifle joint lesions in dogs with non-traumatic cranial cruciate ligament rupture. 】 

Galindo-Zamora V, Dziallas P, Ludwig DC, Nolte I, Wefstaedt P. Galindo-Zamora V, et al. BMC Vet Res. 2013 Feb 28;9:40. doi: 10.1186/1746-6148-9-40. BMC Vet Res. 2013. PMID: 23448526 Free PMC article.

  * 【42† Biceps femoris muscle transposition for treatment of cranial cruciate ligament rupture in small breed dogs. 】 

Tamburro R, Pinna S, Tribuiani AM, Panacea A, Carli F, Venturini A. Tamburro R, et al. J Vet Sci. 2012 Mar;13(1):93-8. doi: 10.4142/jvs.2012.13.1.93. J Vet Sci. 2012. PMID: 22437541 Free PMC article.

  * 【43† Cranial cruciate ligament rupture in small dogs (<15 kg): a narrative literature review. 】 

Brioschi V, Arthurs GI. Brioschi V, et al. J Small Anim Pract. 2021 Dec;62(12):1037-1050. doi: 10.1111/jsap.13404. Epub 2021 Jul 16. J Small Anim Pract. 2021. PMID: 34269419 Review.

  * 【44† Cranial cruciate ligament rupture. Pathogenesis, diagnosis, and postoperative rehabilitation. 】 

Johnson JM, Johnson AL. Johnson JM, et al. Vet Clin North Am Small Anim Pract. 1993 Jul;23(4):717-33. doi: 10.1016/s0195-5616(93)50078-5. Vet Clin North Am Small Anim Pract. 1993. PMID: 8337786 Review.

See all similar articles 

##  References 

  1.     1. Alves J.C, Santos A.M, Jorge P.I. Effect of an oral joint supplement when compared to carprofen in the management of hip osteoarthritis in working dogs. top. Companion Anim. Med. 2017;32(4):126–129. - 【45† PubMed 】 
  2.     1. Alzate Gómez G.J, Tamayo Arango L.J. Comparación de la técnica de sutura supracondilar con la técnica modificada DeAngelis para la corrección de ruptura del ligamento cruzado anterior en perros, Universidad de Antioquia, Facultad de Ciencias Agrarias, Escuela de Medicina Veterinaria, Medellín, Colombia. 2004 
  3.     1. Aragon C.L, Hofmeister E.H, Budsberg S. Systematic review of clinical trials of treatments for osteoarthritis in dogs. J. Am. Vet. Med. Assoc. 2007;230(4):514–521. - 【46† PubMed 】 
  4.     1. Arias S.S.A, Faria R.C.M, Gonçalves M.E. Desempeño clínico de perros con enfermedad articular

Postoperative efficacy of chondroprotectors and diacerein in dogs with osteoarthritis secondary to cranial cruciate ligament disease - PubMed


Free PMC article

Item in Clipboard 

Review

#  Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue 

Stanislav Sukhikh et al. Pharmaceuticals (Basel). 2020.

Free PMC article

 Show details

Display options

Display options 

Format   Abstract PubMed PMID

 Pharmaceuticals (Basel) 

Actions

  * 【28† Search in PubMed 】
  * 【29† Search in NLM Catalog †www.ncbi.nlm.nih.gov】
  * Add to Search 

. 2020 Aug 28;13(9):220.

doi: 10.3390/ph13090220. 

###  Authors 

【30†Stanislav Sukhikh】 【42† 1 】 【43† 2 】, 【33†Olga Babich】 【42† 1 】 【44† 3 】, 【35†Alexander Prosekov】 【44† 3 】, 【36†Nikolai Patyukov】 【42† 1 】, 【37†Svetlana Ivanova】 【45† 4 】 【46† 5 】

###  Affiliations 

  * ^{1} Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia.
  * ^{2} Department of Bionanotechnology, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.
  * ^{3} Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.
  * ^{4} Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.
  * ^{5} Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.

  * PMID:  32872387
  * PMCID:  【40† PMC7557725 †www.ncbi.nlm.nih.gov】 
  * DOI:  【41† 10.3390/ph13090220 †doi.org】 

Item in Clipboard 

Full text links Cite 

Display options

Display options 

Format Abstract PubMed PMID

##  Abstract 

Osteoarthritis is one of the most common diseases of the connective tissue of the elderly. It was found that most epidemiological studies used the Kellgren and Lawrence system for classification of osteoarthritis, which indicates one of the 5 degrees (0-4) of osteoarthritis in various joints according to the radiographic atlas. It has been proven that chondroprotectors are represented by the following active substances: chondroitin sulfate, glucosamine sulfate or hydrochloride, hyaluronic acid, glycosaminoglycans, extraction preparations from animal or plant raw materials. The sources of raw materials for the manufacture of combined chondroprotectors are known, methods for their preparation and use are described. The main drugs on the chondroprotective market are presented. The effectiveness of their use for the treatment of osteoarthritis has been proven. It was found that preparations containing chondroitin sulfate have anti-inflammatory activity, affecting mainly the cellular component of inflammation, stimulate the synthesis of hyaluronic acid and proteoglycans. Methods of treating osteoarthritis using cell therapy (the use of readily available, highly proliferative, and multipotent mesenchymal stromal cells) are presented. 

Keywords:  chondrocytes; chondroprotectors; collagen; hyaluronic acid; osteoarthritis; treatment. 

 【47†PubMed Disclaimer】 

##  Conflict of interest statement 

The authors declare no conflict of interest.

##  Similar articles 

  * 【48† The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. 】 

Kelly GS. Kelly GS. Altern Med Rev. 1998 Feb;3(1):27-39. Altern Med Rev. 1998. PMID: 9600024 Review.

  * 【49† Dynamics of biochemical markers of connective tissue metabolism in patients with knee osteoarthritis during conservative treatment with laser therapy. 】 

Makolinets KV, Makolinets VI, Morozenko DV, Gliebova KV, Danylchenko SI. Makolinets KV, et al. Wiad Lek. 2019;72(5 cz 1):802-806. Wiad Lek. 2019. PMID: 31175776

  * 【50† [Antiresorptive activity of pharmacological chondroitin sulfate in the older age group]. 】 

Shavlovskaya OA, Zolotovskaya IA, Prokofyeva YS. Shavlovskaya OA, et al. Ter Arkh. 2020 Dec 15;92(12):75-79. doi: 10.26442/00403660.2020.12.200448. Ter Arkh. 2020. PMID: 33720577 Russian.

  * 【51† The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits. 】 

Roman-Blas JA, Mediero A, Tardío L, Portal-Nuñez S, Gratal P, Herrero-Beaumont G, Largo R. Roman-Blas JA, et al. Eur J Pharmacol. 2017 Jan 5;794:8-14. doi: 10.1016/j.ejphar.2016.11.015. Epub 2016 Nov 12. Eur J Pharmacol. 2017. PMID: 27845067

  * 【52† Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents. 】 

Gallagher B, Tjoumakaris FP, Harwood MI, Good RP, Ciccotti MG, Freedman KB. Gallagher B, et al. Am J Sports Med. 2015 Mar;43(3):734-44. doi: 10.1177/0363546514533777. Epub 2014 May 27. Am J Sports Med. 2015. PMID: 24866892 Review.

See all similar articles 

##  Cited by 

  * 【53† A Review of Cyclic Phosphatidic Acid and Other Potential Therapeutic Targets for Treating Osteoarthritis. 】 

Tsukahara T, Imamura S, Morohoshi T. Tsukahara T, et al. Biomedicines. 2023 Oct 14;11(10):2790. doi: 10.3390/biomedicines11102790. Biomedicines. 2023. PMID: 37893163 Free PMC article. Review.

  * 【54† Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment. 】 

Shnayder NA, Ashkhotov AV, Trefilova VV, Nurgaliev ZA, Novitsky MA, Petrova MM, Narodova EA, Al-Zamil M, Chumakova GA, Garganeeva NP, Nasyrova RF. Shnayder NA, et al. Int J Mol Sci. 2023 Apr 22;24(9):7692. doi: 10.3390/ijms24097692. Int J Mol Sci. 2023. PMID: 37175399 Free PMC article. Review.

  * 【55† Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: A review. 】 

Sartinah A, Nugrahani I, Ibrahim S, Anggadiredja K. Sartinah A, et al. Heliyon. 2022 Dec 6;8(12):e12039. doi: 10.1016/j.heliyon.2022.e12039. eCollection 2022 Dec. Heliyon. 2022. PMID: 36561673 Free PMC article. Review.

  * 【56† Anti-Inflammatory and Chondroprotective Effects Induced by Phenolic Compounds from Onion Waste Extracts in ATDC-5 Chondrogenic Cell Line. 】 

Paesa M, Ancín-Azpilicueta C, Velderrain-Rodríguez G, Martin-Belloso O, Gualillo O, Osada J, Rodríguez-Yoldi MJ, Mendoza G. Paesa M, et al. Antioxidants (Basel). 2022 Dec 1;11(12):2381. doi: 10.3390/antiox11122381. Antioxidants (Basel). 2022. PMID: 36552589 Free PMC article.

  * 【57† Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis. 】 

Lee YT, Yunus MHM, Ugusman A, Yazid MD. Lee YT, et al. Anti

Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue - PubMed


Unable to load your collection due to an error  
Please try again 

Add  Cancel 

###  Add to My Bibliography 

  *  My Bibliography

Unable to load your delegates due to an error  
Please try again 

Add  Cancel 

##  Your saved search 

Name of saved search:  

Search terms:  

Test search terms 

 Would you like email updates of new search results?   Saved Search Alert Radio Buttons

  *  Yes
  *  No

Email:   (【16†change†www.ncbi.nlm.nih.gov】)

Frequency:   Monthly Weekly Daily

Which day?   The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday

Which day?   Sunday Monday Tuesday Wednesday Thursday Friday Saturday

Report format:   Summary Summary (text) Abstract Abstract (text) PubMed

Send at most:   1 item 5 items 10 items 20 items 50 items 100 items 200 items

 Send even when there aren't any new results 

Optional text in email:  

Save  Cancel 

##  Create a file for external citation management software 

Create file  Cancel 

##  Your RSS Feed 

Name of RSS Feed:  

Number of items displayed:   5 10 15 20 50 100

Create RSS  Cancel 

RSS Link  Copy 

### Actions 

Cite 

Collections

Add to Collections

  * Create a new collection
  * Add to an existing collection

Name your collection: 

Name must be less than 100 characters 

Choose a collection: 

Unable to load your collection due to an error   
Please try again

Add  Cancel 

Display options

Display options 

Format Abstract PubMed PMID

###  Share 

  *   *   * Permalink 

Copy

###  Page navigation 

  * 【17† Title & authors 】 
  * 【18† Abstract 】 
  * 【19† Similar articles 】 
  * 【20† Publication types 】 
  * 【21† MeSH terms 】 
  * 【22† Substances 】 
  * 【23† Related information 】 
  * 【24† LinkOut - more resources 】 

Title & authors Abstract Similar articles Publication types MeSH terms Substances Related information LinkOut - more resources

Review

 Ter Arkh 

Actions

  * 【25† Search in PubMed 】
  * 【26† Search in NLM Catalog †www.ncbi.nlm.nih.gov】
  * Add to Search 

. 2013;85(5):92-4.

#  [Strategy for the use of chondroprotectors in osteoarthrosis] 

[Article in Russian] 

【27†S M Noskov】, 【28†A A Lavrukhina】, 【29†K Yu Shirokova】, 【30†A A Pryanichnikova】

  * PMID:  23819346

Item in Clipboard 

Review

#  [Strategy for the use of chondroprotectors in osteoarthrosis] 

[Article in Russian] 

S M Noskov et al. Ter Arkh. 2013.

 Show details

Display options

Display options 

Format   Abstract PubMed PMID

 Ter Arkh 

Actions

  * 【25† Search in PubMed 】
  * 【26† Search in NLM Catalog †www.ncbi.nlm.nih.gov】
  * Add to Search 

. 2013;85(5):92-4.

###  Authors 

【27†S M Noskov】, 【28†A A Lavrukhina】, 【29†K Yu Shirokova】, 【30†A A Pryanichnikova】

  * PMID:  23819346

Item in Clipboard 

Cite 

Display options

Display options 

Format Abstract PubMed PMID

##  Abstract 

Symptomatic slow-acting drugs (chondroprotectors) as different dosage forms have widespread application in the treatment of osteoarthrosis (OA) at different locations. The literature review considers their possible effect on carbohydrate metabolism, which is particularly important due to the high prevalence of diabetes mellitus in patients with OA. Current clinical recommendations for the use of chondroprotectors in the therapy of OA are given. 

 【31†PubMed Disclaimer】 

##  Similar articles 

  * 【32† [Role of slow-acting anti-arthritic agents in osteoarthritis (chondroitin sulfate, glucosamine, hyaluronic acid)]. 】 

Aubry-Rozier B. Aubry-Rozier B. Rev Med Suisse. 2012 Mar 14;8(332):571-2, 574, 576. Rev Med Suisse. 2012. PMID: 22455150 French.

  * 【33† Future therapeutics for osteoarthritis. 】 

Martel-Pelletier J, Wildi LM, Pelletier JP. Martel-Pelletier J, et al. Bone. 2012 Aug;51(2):297-311. doi: 10.1016/j.bone.2011.10.008. Epub 2011 Oct 17. Bone. 2012. PMID: 22037003 Review.

  * 【34† Guidelines for testing slow acting drugs in osteoarthritis. 】 

Lequesne M, Brandt K, Bellamy N, Moskowitz R, Menkes CJ, Pelletier JP, Altman R. Lequesne M, et al. J Rheumatol Suppl. 1994 Sep;41:65-71; discussion 72-3. J Rheumatol Suppl. 1994. PMID: 7799389

  * 【35† [The relation between the level of antibodies to the glycosaminoglycans of the cartilage in patients with osteoarthritis and the efficacy of treatment with chondroprotectors]. 】 

Zavodovskiĭ BV, Kovalenko EA, Fofanova NA, Novikova OV, Zborovskiĭ AB. Zavodovskiĭ BV, et al. Ter Arkh. 1999;71(5):47-50. Ter Arkh. 1999. PMID: 10399231 Russian.

  * 【36† Methodology of clinical trials in hand osteoarthritis. Issues and proposals. 】 

Maheu E, Dreiser RL, Lequesne M. Maheu E, et al. Rev Rhum Engl Ed. 1995 Jun;62(6 Suppl 1):55S-62S. Rev Rhum Engl Ed. 1995. PMID: 7583183 Review.

See all similar articles 

##  Publication types 

  * English Abstract 

Actions

    * 【37† Search in PubMed 】
    * 【38† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Review 

Actions

    * 【39† Search in PubMed 】
    * 【40† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

##  MeSH terms 

  * Antirheumatic Agents / administration & dosage 

Actions

    * 【41† Search in PubMed 】
    * 【42† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Antirheumatic Agents / therapeutic use* 

Actions

    * 【43† Search in PubMed 】
    * 【42† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Carbohydrate Metabolism / drug effects* 

Actions

    * 【44† Search in PubMed 】
    * 【45† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Diabetes Mellitus / epidemiology 

Actions

    * 【46† Search in PubMed 】
    * 【47† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Humans 

Actions

    * 【48† Search in PubMed 】
    * 【49† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Osteoarthritis / drug therapy* 

Actions

    * 【50† Search in PubMed 】
    * 【51† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

  * Osteoarthritis / physiopathology 

Actions

    * 【52† Search in PubMed 】
    * 【51† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

##  Substances 

  * Antirheumatic Agents 

Actions

    * 【53† Search in PubMed 】
    * 【54† Search in MeSH †www.ncbi.nlm.nih.gov】
    * Add to Search 

##  Related information 

  * 【55† MedGen †www.ncbi.nlm.nih.gov】

##  LinkOut - more resources 

  * ### Medical

    * 【56† MedlinePlus Health Information †medlineplus.gov】

[x]

Cite

Copy   Download .nbib .nbib

Format: AMA  APA  MLA  NLM 

 Send To

  * Clipboard
  * Email
  * Save
  * 【14†My Bibliography†account.ncbi.nlm.nih.gov】
  * 【15†Collections†account.ncbi.nlm.nih.gov】
  * Citation Manager

[x]

NCBI Literature Resources

【57†MeSH†www.ncbi.nlm.nih.

[Strategy for the use of chondroprotectors in osteoarthrosis] - PubMed

Estudios científicos sobre condroprotectores y perros

Answers your questions about your dog's behavior or health problems based on scientific studies. Available in English and Spanish.