Statins and Cellular Effects
Please assess this commentary:
Magic trick - Take Statins, choke off the life cycle of liver cells so that Reductase kicks into overdrive to “trick” liver cells into mass producing cholesterol receptors that soak up all the supposedly “bad” blood cholesterol - most of which is normally made by the liver via the Mevalonate Pathway in the first place. Get blood tested and EUREKA - just like magic - LDL “bad” cholesterol is lower.
Shifting cholesterol from the blood into cells is one way to serially kill cells by apoptosis. Another way to kill cells is to block cell cycles. STATINS DO BOTH ! Like the magic trick with the disappearing Dove, lowering LDL cholesterol is the grand illusion
The bird didn’t disappear, and the LDL just got shunted into muscle and liver cells until those cells died. The biggest trick of all is imagining that this performance prevents heart disease. Watch again. Did you see it this time ?
The commentary on statins presents a critical view, suggesting that statins may induce cell death through pathways like apoptosis. To assess the accuracy of these claims, let's look at recent research on the effects of statins on liver cells and apoptosis:
Statins and Cellular Pathways: Statins are known for their cholesterol-lowering effects and have been found to have anti-inflammatory, anti-tumor, and immunomodulatory properties. They can affect various cellular pathways, including apoptosis, through mechanisms such as the AMPK pathway. This pathway plays a critical role in metabolism homeostasis and affects processes like cell proliferation and apoptosis in cancer cells. Statins are found to activate AMPK, which inhibits cell proliferation and induces apoptosis in cancer cells, while also exerting cardio-protective effects through inhibition of inflammation and fibrosis, and promotion of angiogenesis (Dehnavi et al., 2021).
Statins and Liver Cell Response: At the proteome level, statins like atorvastatin have shown pleiotropic effects including changes in protein abundances related to lipid metabolism, cellular stress response, and apoptosis in liver cells. This indicates a complex response of liver cells to statin treatment, impacting not just cholesterol synthesis but also other cellular functions (Xiao et al., 2015).
Lovastatin and Apoptosis in Liver Cancer Cells: Lovastatin has been shown to induce apoptosis in liver cancer cells by increasing intracellular levels of reactive oxygen species (ROS). This induction of apoptosis is linked to mitochondrial and endoplasmic reticulum stress pathways triggered by ROS accumulation (Wang et al., 2017).
Simvastatin and Endothelial Cell Apoptosis: In another study, simvastatin was found to increase the susceptibility of liver sinusoid endothelial cells to apoptosis induced by factors like Fas and TNF-alpha [(Acquavella et al., 2010)](https://consensus.app/papers/effect-simvastatin-cell-apoptosis-mediated-tnfalpha-acquavella/2a5f64
Pleiotropic Effects of Statins: Statins' pleiotropic effects are also linked to the inhibition of isoprenoids synthesis, which can block prenylation of proteins involved in cellular signaling pathways that regulate cell development, growth, and apoptosis. Statins target cholesterol synthesis in the liver, reducing whole-body cholesterol levels. This reduction may force other organs to increase their cholesterol synthesis capacity, especially when statins have limited access to extra-hepatic tissues (Ahmadi et al., 2019).
Statins in Cancer Treatment and Prevention: Statins are recognized for their anti-tumor activity, largely due to their ability to induce apoptosis in cancer cells. They are also involved in the regulation of histone acetylation levels, which can affect gene activity involved in proliferation, differentiation, and apoptosis. This property is linked to their potential use in cancer treatment and prevention (Grabarek et al., 2021).
In conclusion, while the commentary highlights potential negative effects of statins, research indicates a more complex interaction of statins with cellular processes. Statins do induce apoptosis, especially in cancer cells, and affect various cellular pathways, but they also have protective roles in certain conditions like cardiovascular diseases and potentially in cancer prevention and treatment. Thus, the characterization of statins as solely harmful oversimplifies their multifaceted impact on human physiology.